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1.
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell
; 172(4): 719-730.e14, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29398112
2.
Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats.
Mol Psychiatry
; 28(9): 3829-3841, 2023 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-37783788
3.
Conformational transitions of the serotonin 5-HT3 receptor.
Nature
; 563(7730): 275-279, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30401839
4.
Strychnine and its mono- and dimeric analogues: a pharmaco-chemical perspective.
Nat Prod Rep
; 39(10): 1910-1937, 2022 10 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35380133
5.
Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype.
Int J Mol Sci
; 23(15)2022 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35955932
6.
Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr128Ala variant (rs2257020) in Xenopus oocytes.
Pharmacol Res
; 169: 105653, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33962015
7.
Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery.
J Org Chem
; 86(12): 8248-8262, 2021 06 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34061521
8.
C-2-Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors.
J Nat Prod
; 84(2): 382-394, 2021 02 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33596384
9.
11-Aminostrychnine and N-(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors.
J Nat Prod
; 82(8): 2332-2336, 2019 08 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31385511
10.
Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist.
J Pharmacol Exp Ther
; 361(3): 441-453, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28360333
11.
A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHßE.
Beilstein J Org Chem
; 13: 988-994, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28684978
12.
Convergent 18F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands.
Bioorg Med Chem
; 24(21): 5353-5356, 2016 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27624522
13.
Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists.
J Nat Prod
; 79(12): 2997-3005, 2016 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-27966945
14.
Probing α4ßδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4ß1δ/α4ß3δ receptor agonist on tonic and phasic inhibition in rat brain.
J Neurosci
; 34(49): 16256-72, 2014 Dec 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25471566
15.
A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude).
Mol Pharmacol
; 88(2): 401-20, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26056160
16.
The metabolic impact of ß-hydroxybutyrate on neurotransmission: Reduced glycolysis mediates changes in calcium responses and KATP channel receptor sensitivity.
J Neurochem
; 132(5): 520-31, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25330271
17.
The glutamate transport inhibitor DL-Threo-ß-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells.
BMC Cancer
; 15: 411, 2015 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-25981639
18.
Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.
J Neurosci
; 33(3): 1068-87, 2013 Jan 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-23325245
19.
Elucidation of molecular impediments in the α6 subunit for in vitro expression of functional α6ß4* nicotinic acetylcholine receptors.
J Biol Chem
; 288(47): 33708-33721, 2013 Nov 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-24085295
20.
Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs.
Neurochem Res
; 39(10): 1964-79, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24682739